Exertional rhabdomyolysis: Relevance of clinical and laboratory findings, and clues for investigation

Some degree of exertional rhabdomyolysis (ER), striated muscle breakdown associated with strenuous exercise, is a well-known phenomenon associated with endurance sports. However in rare cases, severe and/or recurrent ER is a manifestation of an underlying condition, which puts patients at risk for s...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2019-03, Vol.47 (2), p.128-133
Main Authors: Heytens, Karel, De Ridder, Willem, De Bleecker, Jan, Heytens, Luc, Baets, Jonathan
Format: Article
Language:English
Subjects:
Age
Anesthesia
Biopsy
Complaints
Complications
Creatine kinase
Diagnostic use
Diseases
Exercise
Fever
Hyperthermia
Laboratories
Muscles
Mutation
NMR
Nuclear magnetic resonance
Pain
Patients
Physiological aspects
Physiology
Professional relationships
Rhabdomyolysis
Wounds and injuries
Writers
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Summary:Some degree of exertional rhabdomyolysis (ER), striated muscle breakdown associated with strenuous exercise, is a well-known phenomenon associated with endurance sports. However in rare cases, severe and/or recurrent ER is a manifestation of an underlying condition, which puts patients at risk for significant morbidity and mortality. Selecting the patients that need a diagnostic work up of an acute rhabdomyolysis episode is an important task. Based on the diagnostic work up of three illustrative patients treated in our hospital, retrospectively using the 'RHABDO' screening tool, we discuss the clinical and biochemical clues that should trigger further investigation for an underlying condition. Finally, we describe the most common genetic causes of this clinical syndrome.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X19835830