Fatal Yellow Fever in a Kidney Transplant Patient

Abstract A kidney-transplanted patient, unvaccinated against yellow fever (YF), developed high fever, progressed rapidly to hepatic insufficiency and coma, and died 8 days later. Real-time polymarase chain reaction for YF virus collected on the seventh day of symptoms was positive. Autopsy showed di...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-01, Vol.70 (1), p.144-148
Main Authors: Pierrotti, Lígia C, Duarte-Neto, Amaro N, Song, Alice T W, Ventura, Carlucci G, David-Neto, Elias, Azevedo, Luiz S
Format: Article
Language:English
Subjects:
Humans
Kidney Transplantation - adverse effects
Yellow Fever - diagnosis
Yellow Fever Vaccine
Yellow fever virus - genetics
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Summary:Abstract A kidney-transplanted patient, unvaccinated against yellow fever (YF), developed high fever, progressed rapidly to hepatic insufficiency and coma, and died 8 days later. Real-time polymarase chain reaction for YF virus collected on the seventh day of symptoms was positive. Autopsy showed disseminated infection and midzonal hepatitis with apoptotic hepatocytes and minimal inflammatory reaction.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz389