A comparative phylogenomic analysis of avian avulavirus 1 isolated from non-avian hosts: conquering new frontiers of zoonotic potential among species

A number of avian avulavirus 1 (AAvV 1) isolates have been reported from avian and non-avian hosts worldwide with varying clinical consequences. In this regard, robust surveillance coupled with advanced diagnostics, genomic analysis, and disease modelling has provided insight into the molecular epid...

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Bibliographic Details
Published in:Archives of virology 2019-07, Vol.164 (7), p.1771-1780
Main Authors: Ul-Rahman, Aziz, Shabbir, Muhammad Zubair
Format: Article
Language:English
Subjects:
Adaptation, Physiological - genetics
Amino Acid Sequence
Animals
Avulavirus - classification
Avulavirus - genetics
Avulavirus - isolation & purification
Avulavirus Infections - epidemiology
Biomedical and Life Sciences
Biomedicine
Bird Diseases - virology
Epidemiology
Evolution
Genomic analysis
Genotype
Genotypes
Host Specificity - genetics
Humans
Infectious Diseases
Medical Microbiology
Mink
Molecular Epidemiology
Original Article
Phylogeny
Sequence Alignment
Swine
Virology
Zoonoses
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Summary:A number of avian avulavirus 1 (AAvV 1) isolates have been reported from avian and non-avian hosts worldwide with varying clinical consequences. In this regard, robust surveillance coupled with advanced diagnostics, genomic analysis, and disease modelling has provided insight into the molecular epidemiology and evolution of this virus. The genomic and evolutionary characteristics of AAvV 1 isolates originating from avian hosts have been well studied, but those originating from non-avian hosts have not. Here, we report a comparative genomic and evolutionary analysis of so-far reported AAvV 1 isolates originating from hosts other than avian species (humans, mink and swine). Phylogenetic analysis showed that AAvV 1 isolates clustered in five distinct genotypes (I, II, VI, VII and XIII). Further analysis revealed clustering of isolates into clades distant enough to be considered distinct subgenotypes, along with a few substitutions in several significant motifs. Although further investigation is needed, the clustering of AAvV 1 strains isolated from non-avian hosts into novel subgenotypes and the presence of substitutions in important structural and biological motifs suggest that this virus can adapt to novel hosts and therefore could have zoonotic potential.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-019-04276-z