Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound‐Y (C‐Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB‐irradiated NHDFs and its potential for use as an anti...

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Published in:Photochemistry and photobiology 2019-11, Vol.95 (6), p.1412-1423
Main Authors: Liu, Xiao‐yi, Xiao, Yong‐Kun, Hwang, Eunson, Haeng, Jeong Jee, Yi, Tae‐Hoo
Format: Article
Language:English
Subjects:
Antioxidants
Embryos
Functional foods & nutraceuticals
Ginseng
Ginsenosides
Hyperpigmentation
MAP kinase
Melanin
Metabolites
NF-AT protein
Nuclear transport
Panax ginseng
Phosphorylation
Procollagen
Secretion
Skin
Transforming growth factor-b1
Translocation
Tyrosinase
Ultraviolet radiation
Vascular endothelial growth factor
Zebrafish
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Summary:Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound‐Y (C‐Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB‐irradiated NHDFs and its potential for use as an antihyperpigmentation agent through ginsenoside C‐Y as a functional food and cosmetic ingredient. Ginsenoside C‐Y is a natural antioxidant isolated from the American ginseng PDD‐ginsenoside. Our data showed that ginsenoside C‐Y block UVB‐exposed ROS, restrict MMP‐1 production and promote procollagen type I synthesis. Interestingly, ginsenoside C‐Y suppresses UVB‐exposed VEGF, and TNF‐α secretion, could be related with NFAT signal path. Ginsenoside C‐Y has exhibited photoaging effects by increasing TGF‐β1 level, fortifying Nrf2 nuclear translocation and restricting AP‐1 and MAPK phosphorylation. Assessment of the melanogenic response indicated that ginsenoside C‐Y inhibited melanin secretion and tyrosinase activity and decreased melanin content in Melan‐a and zebrafish embryos. These results suggest that ginsenoside C‐Y can be used as a potential botanical agent to protect premature skin from UVB‐induced photodamage and prevent skin hyperpigmentation. The photoprotective efficacy of ginsenoside C‐Y against UVB‐induced skin photodamage.
ISSN:0031-8655
1751-1097
DOI:10.1111/php.13116