Viral load and duration of BK polyomavirus viraemia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies

Abstract Background Polyomavirus BK (BKV) infection of the renal allograft causes destructive tissue injury with inflammation and subsequent fibrosis. Methods Using a prospective cohort of patients after kidney transplantation performed between 2003 and 2012, we investigated the role of BKV viraemia...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2019-11, Vol.34 (11), p.1970-1978
Main Authors: Reischig, Tomas, Kacer, Martin, Hes, Ondrej, Machova, Jana, Nemcova, Jana, Kormunda, Stanislav, Pivovarcikova, Kristyna, Bouda, Mirko
Format: Article
Language:English
Subjects:
BK Virus - isolation & purification
BK Virus - pathogenicity
Disease Progression
Female
Fibrosis - etiology
Fibrosis - pathology
Graft Survival
Humans
Kidney Diseases - etiology
Kidney Diseases - pathology
Kidney Transplantation - adverse effects
Male
Middle Aged
Polyomavirus Infections - complications
Polyomavirus Infections - virology
Prospective Studies
Transplantation, Homologous
Tumor Virus Infections - complications
Tumor Virus Infections - virology
Viral Load
Viremia - complications
Viremia - virology
Virus Replication
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Summary:Abstract Background Polyomavirus BK (BKV) infection of the renal allograft causes destructive tissue injury with inflammation and subsequent fibrosis. Methods Using a prospective cohort of patients after kidney transplantation performed between 2003 and 2012, we investigated the role of BKV viraemia in the development and progression of interstitial fibrosis and tubular atrophy (IFTA). The primary outcome was moderate-to-severe IFTA assessed by protocol biopsy at 36 months. Results A total of 207 consecutive recipients were enrolled. Of these, 57 (28%) developed BKV viraemia with 10 (5%) cases of polyomavirus-associated nephropathy (PVAN). Transient (
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfz061