Cause of pleuroparenchymal fibroelastosis following allogeneic hematopoietic stem cell transplantation

• Published in: Respiratory investigation 2019-07, Vol.57 (4), p.321-324
• Main Authors: Higo, Hisao, Miyahara, Nobuaki, Taniguchi, Akihiko, Maeda, Yoshinobu, Kiura, Katsuyuki
• Format: Article
• Language: English
• Subjects: Alkylating agents; Alkylating Agents - adverse effects; Allogeneic hematopoietic stem cell transplantation; Allografts; Bronchiolitis Obliterans - complications; Chronic Disease; Chronic graft-versus-host disease; Elastic Tissue - pathology; Graft vs Host Disease - complications; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Lung Diseases, Interstitial - etiology; Lung Diseases, Interstitial - pathology; Parenchymal Tissue - pathology; Pleural Diseases - etiology; Pleural Diseases - pathology; Pleuroparenchymal fibroelastosis; Postoperative Complications - etiology; Postoperative Complications - pathology
• ISSN: 2212-5345; 2212-5353
• DOI: 10.1016/j.resinv.2019.04.003

Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications after hematopoietic stem cell transplantation (HSCT). Pleuroparenchymal fibroelastosis (PPFE) is a LONIPC, but its etiology remains elusive. Chronic graft-versus-host disease (cGVHD) and alkylating agents used for conditioning have been considered possible causes of PPFE. Therefore, to investigate the primary cause of PPFE in allogeneic HSCT, we compared three secondary PPFE groups, namely, the post-lung-transplantation, post-autologous-HSCT or chemotherapy-alone, and post-allogeneic-HSCT groups, and focused on the coexistence of bronchiolitis obliterans (BO), a typical phenotype of cGVHD. We found a trend towards higher rates of PPFE with BO in the post-allogeneic-HSCT and post-lung-transplantation groups (71% and 90%, respectively) than in the post-autologous-HSCT or chemotherapy-alone group (25%). The incidence of BO following allogeneic HSCT is reportedly