Prevention of infections produced by Escherichia coli and Listeria monocytogenes by feeding milk fermented with lactobacilli

Challenge studies were set up feeding Lactobacillus casei and Lactobacillus acidophilus fermented milk and two different pathogenic microorganisms: Listeria monocytogenes and enteroinvasive Escherichia coli. Mice were fed for 8 consecutive days with fermented milk and then challenged with the pathog...

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Bibliographic Details
Published in:Journal of food protection 1993-05, Vol.56 (5), p.401-405
Main Authors: NADER DE MACIAS, M. E, ROMERO, N. C, APELLA, M. C, GONZALEZ, S. N, OLIVER, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
contaminacion
contamination
control de enfermedades
controle de maladies
cultured milk
disease control
Escherichia coli
Food industries
Fundamental and applied biological sciences. Psychology
Lactobacillus
lactobacillus acidophilus
lait fermente
leche fermentada
Listeria monocytogenes
mice
Milk and cheese industries. Ice creams
raton
souris
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Summary:Challenge studies were set up feeding Lactobacillus casei and Lactobacillus acidophilus fermented milk and two different pathogenic microorganisms: Listeria monocytogenes and enteroinvasive Escherichia coli. Mice were fed for 8 consecutive days with fermented milk and then challenged with the pathogens. The survival rate in control mice was 62% for Listeria and 83% for E. coli, while 100% protection was observed for the 20 d per vial in treated mice. Colonization of the liver and spleen by E. coli was markedly inhibited by pretreatment with fermented milk: the pathogen was not detected on the 5th day postchallenge. In the Listeria challenged mice, the pathogen was present in 1 to 2 log units lower than control up the 10th day. The levels of antipathogen sera and intestinal antibodies were 2 to 4 times higher in the treated mice, with lower values in the Listeria treated mice. The mechanism of protection in both types of infections was discussed. The results obtained suggested that milk fermented with L. casei and L. acidophilus could be used as a prophylactic against selected infections.
ISSN:0362-028X
1944-9097
DOI:10.4315/0362-028X-56.5.401