Invasive ductal carcinoma with coexisting ductal carcinoma in situ (IDC/DCIS) versus pure invasive ductal carcinoma (IDC): a comparison of clinicopathological characteristics, molecular subtypes, and clinical outcomes

Purpose Ductal carcinoma in situ (DCIS) is widely recognized as the precursor of invasive ductal carcinoma (IDC). We aimed to analyze the clinicopathological characteristics and clinical outcomes of coexisting DCIS component in IDC and its clinical significance according to molecular subtypes. Metho...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2019-07, Vol.145 (7), p.1877-1886
Main Authors: Goh, Chih Wan, Wu, Jiayi, Ding, Shuning, Lin, Caijin, Chen, Xiaosong, Huang, Ou, Chen, Weiguo, Li, Yafen, Shen, Kunwei, Zhu, Li
Format: Article
Language:English
Subjects:
Breast cancer
Cancer Research
Clinical outcomes
Coexistence
ErbB-2 protein
Hematology
Internal Medicine
Invasiveness
Lymph nodes
Lymphatic system
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Oncology
Original Article – Clinical Oncology
Patients
Surgery
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Summary:Purpose Ductal carcinoma in situ (DCIS) is widely recognized as the precursor of invasive ductal carcinoma (IDC). We aimed to analyze the clinicopathological characteristics and clinical outcomes of coexisting DCIS component in IDC and its clinical significance according to molecular subtypes. Methods Data from 3001 patients with IDC (79.4%) and IDC/DCIS (20.6%) who underwent surgery from January 2009 to June 2016 were retrospectively assessed. The clinical outcomes of IDC with coexistent DCIS in different molecular subtypes were evaluated. Results IDC/DCIS patients were more likely to be younger ( P 
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-019-02930-2