Diagnostic Power of Selected Cytokines, MMPs and TIMPs in Ovarian Cancer Patients - ROC Analysis

The aim of the study was to identify new non-invasive ovarian cancer (OC) tumor markers. In postmenopausal ovarian cancer patients and in a control group (benign ovarian lesions and healthy subjects), preoperative plasma levels of cytokines, metalloproteinases and their tissue inhibitors were determ...

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Bibliographic Details
Published in:Anticancer research 2019-05, Vol.39 (5), p.2575-2582
Main Authors: Będkowska, Grażyna Ewa, Piskór, Barbara, Gacuta, Ewa, Zajkowska, Monika, Osada, Joanna, Szmitkowski, Maciej, Dąbrowska, Milena, Ławicki, Sławomir
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - blood
CA-125 Antigen - blood
Carcinoma, Ovarian Epithelial - blood
Carcinoma, Ovarian Epithelial - pathology
Cytokines - blood
Female
Healthy Volunteers
Humans
Membrane Proteins - blood
Metalloproteases - blood
Middle Aged
Neoplasms - blood
Neoplasms - pathology
Predictive Value of Tests
Prognosis
Proteins - metabolism
ROC Curve
Tissue Inhibitor of Metalloproteinases - blood
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Summary:The aim of the study was to identify new non-invasive ovarian cancer (OC) tumor markers. In postmenopausal ovarian cancer patients and in a control group (benign ovarian lesions and healthy subjects), preoperative plasma levels of cytokines, metalloproteinases and their tissue inhibitors were determined using ELISA while those of CA125 and HE4 by chemiluminescent microparticle immunoassay methods. The diagnostic sensitivity (SE) value was the highest for HE4 and MMP-7 (78.0%). The diagnostic specificity (SP) for M-CSF, VEGF and MMP-9 was 95.2%, 95.2% and 95.7%, respectively. The highest positive predictive value (PPV) for M-CSF and MMP-9 was ~84.6% and negative predictive value (NPV) for MMP-7 and HE4 was ~87.6%. The biggest areas under the ROC curve were obtained for the combination of VEGF, MMP-7 or MMP-9 with HE4+CA125 (0.9130-0.9234), but not for CA125+HE4 (0.8260). Our research confirms the validity of combining classic markers with new markers to improve the diagnostic power of CA125 and HE4.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13380