Removal of DNA adducts

DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia...

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Bibliographic Details
Published in:Medical hypotheses 2019-06, Vol.127, p.11-14
Main Authors: Puri, B.K., Ijeh, C., Monro, J.A.
Format: Article
Language:English
Subjects:
Adduct
Administration, Intravenous
Chromatography, Gas
DNA
DNA Adducts - isolation & purification
Fatty Acids - administration & dosage
Female
Humans
Hyperthermia
Hyperthermia, Induced - methods
Male
Middle Aged
Models, Biological
Neoplasms - genetics
Neoplasms - therapy
Oligonucleotide Array Sequence Analysis
Parkinson Disease - therapy
Phospholipids - administration & dosage
Reproducibility of Results
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Summary:DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair. The number of DNA adducts and total DNA adduct concentrations were measured in 104 patients who underwent one or more of the three intervention programmes. DNA adduct assessments were carried out on extracted genomic DNA by gas-liquid chromatography, with any DNA adducts found being localised using DNA microarrays. The baseline median number of DNA adducts was 2. The follow-up median number of adducts was highly significantly lower at 0 (p 
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.03.031