Correlation of Expression of CHI3L1 and Nogo-A and their Role in Angiogenesis in Invasive Ductal Breast Carcinoma

• Published in: Anticancer research 2019-05, Vol.39 (5), p.2341-2350
• Main Authors: Rusak, Agnieszka, Jablonska, Karolina, Piotrowska, Aleksandra, Grzegrzolka, Jedrzej, Wojnar, Andrzej, Dziegiel, Piotr
• Format: Article
• Language: English
• Subjects: Aged; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - pathology; Cell Line, Tumor; Cell Proliferation - genetics; Chitinase-3-Like Protein 1 - genetics; Female; Gene Expression Regulation, Neoplastic - genetics; Humans; Middle Aged; Neovascularization, Pathologic - genetics; Nogo Proteins - genetics; Receptors, Cell Surface - genetics; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor C - genetics; Vascular Endothelial Growth Factor D - genetics
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.13351

Chitinase 3 like 1 (CHI3L1) is a secretion glycoprotein. Elevated levels of this protein are observed in cancer diseases. The biological role of CHI3L1 is not yet fully known, but the connection between CHI3L1 and angiogenesis has been shown. Recent reports also describe the association of Nogo isoforms and Nogo-B receptor (NgBR) with a proliferative potential, cancer cell invasiveness, and angiogenesis. The aim of this study was to evaluate the levels of CHI3L1, Nogo-A, Nogo-A/B, and NgBR and correlate them with clinical-pathological data, to study their role in angiogenesis in invasive ductal breast carcinoma (IDC). A total of 77 IDC cases were used in the study. Immunohistochemistry was used to determine the level of expression of CHI3L1, Nogo-A, Nogo-A/B, NgBR and vascular endothelial growth factors (VEGFA, VEGFC and VEGFD). The obtained results were subjected to statistical analysis including clinicalpathological data. A statistically significant positive correlation of CHI3L1 and Nogo-A expression (r=0.474, p>0.0001) and a positive correlation of Nogo-A and VEGFC expression (r=0.280, p=0.013) were found. CHI3L1 and Nogo-A are important in angiogenesis in IDC.