Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis

Obesity is one of the main causes of inflammation. Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers. This systematic review and meta-analysis is aimed at describing the effect of bariatric surgery on C-reactive protein (CRP), inter...

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Bibliographic Details
Published in:Obesity surgery 2019-08, Vol.29 (8), p.2631-2647
Main Authors: Askarpour, Moein, Khani, Dana, Sheikhi, Ali, Ghaedi, Ehsan, Alizadeh, Shahab
Format: Article
Language:English
Subjects:
Bariatric Surgery
Biomarkers - blood
C-Reactive Protein - analysis
Gastrointestinal surgery
Humans
Inflammation - blood
Inflammation - complications
Inflammation Mediators - blood
Interleukin-6 - blood
Medicine
Medicine & Public Health
Meta-analysis
Obesity - blood
Obesity - complications
Obesity - epidemiology
Obesity - surgery
Postoperative Period
Review Article
Surgery
Systematic review
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-TNF
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Summary:Obesity is one of the main causes of inflammation. Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers. This systematic review and meta-analysis is aimed at describing the effect of bariatric surgery on C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α). PubMed/Medline and Scopus were systematically searched for all eligible studies from inception to June 2018. Results are expressed as weighted mean difference (MD) with 95% confidence intervals (CI) using a random effects model. Overall, 116 studies which evaluated serum CRP, IL-6, and TNF-α after bariatric surgery were included. Pooled effect size showed significant reduction in serum CRP (− 5.30 mg/l, 95% CI − 5.46, − 5.15, P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-019-03926-0