Prostate cancer biomarkers detection using nanoparticles based electrochemical biosensors

• Published in: Biosensors & bioelectronics 2019-07, Vol.137, p.213-221
• Main Authors: Singh, Sima, Gill, Atal A.S., Nlooto, Manimbulu, Karpoormath, Rajshekhar
• Format: Article
• Language: English
• Subjects: Biomarkers; Electroanalysis; Electrochemical detection; Modified electrode; Nanomaterials; Prostate cancer (PCa)
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2019.03.065

Prostate cancer (PCa) is the most prevalent cancer with a high mortality rate. The early and accurate detection of PCa can significantly reduce mortality and saves lives. Hence, the nanomaterials based electrochemical nano-biosensors for PCa biomarkers will be the excellent alternative for diagnosis, detection and management of disease condition. In this review, we present a concise summary of the latest attainment and advancement in the use of nanoparticles for the diagnosis of PCa biomarkers. This review highlighted the importance of applying specific biomarkers along with nanomaterials like gold, magnetic, carbon nanotubes, and many other materials for developing electrochemical nanobiosensors in PCa detection. In addition to a summary on PCa detection, we further ensure future perspectives in PCa biomarkers detection, sensitivity, simplicity, rapidity, accuracy, cost-effectiveness and succeeding optimizations of novel technologies for more feasibility. Finally, closing remarks and an outlook conclude the review. •This review aims to give an overview of recent advances in prostate cancer (PCa) biomarkers detection by electrochemical biosensors.•We gave an importance of use of nanomaterials based electrochemical biosensors in early detection of PCa.•Fabrication of low-cost nanotechnology-based PCa biomarkers with good sensitivity, selectivity and stability have been discussed.