Association of autoimmunity and cancer: An emphasis on proteolytic enzymes

Cancer and autoimmune diseases are the two devastating conditions that together constitute a leading health problem worldwide. The rising burden of these disorders in the developing world demands a multifaceted approach to address the challenges it poses. Understanding the root causes and specific m...

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Bibliographic Details
Published in:Seminars in cancer biology 2020-08, Vol.64, p.19-28
Main Authors: Tabrez, Shams, Jabir, Nasimudeen R., Khan, Mohammad Imran, Khan, Mohd Shahnawaz, Shakil, Shazi, Siddiqui, Ali Nasir, Zaidi, Syed Kashif, Ahmed, Bakrudeen Ali, Kamal, Mohammad Amjad
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Autoimmune Diseases - complications
Autoimmune Diseases - enzymology
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity - immunology
Cancer
Cytokines - metabolism
Humans
Immune response
Inflammation
Neoplasms - complications
Neoplasms - enzymology
Neoplasms - immunology
Neoplasms - pathology
Peptide Hydrolases - immunology
Peptide Hydrolases - metabolism
Proteolytic enzymes
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Summary:Cancer and autoimmune diseases are the two devastating conditions that together constitute a leading health problem worldwide. The rising burden of these disorders in the developing world demands a multifaceted approach to address the challenges it poses. Understanding the root causes and specific molecular mechanisms by which the progression of the diseases takes place is need of the hour. A strong inflammatory background and common developmental pathways, such as activation of immune cells, proliferation, increased cell survival and migration which are controlled by growth factors and inflammatory cytokines have been considered as the critical culprits in the progression and complications of these disorders. Enzymes are the potential immune modulators which regulate various inflammatory events and can break the circulating immune complexes via macrophages production. In the current manuscript, we have uncovered the possible role of proteolytic enzymes in the pathogenesis and progression of cancer and autoimmune diseases. In the light of the available scientific literature, we advocate in-depth comprehensive studies which will shed light towards the role of proteolytic enzymes in the modulation of inflammatory responses in cancer and autoimmune diseases together.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2019.05.006