Rhodium(III)-Catalyzed Intramolecular Olefin Hydroarylation of Aromatic Aldehydes Using a Transient Directing Group

A Rh­(III)-catalyzed intramolecular olefin hydroarylation of aromatic aldehydes with a transient directing group has been described. The bidentate directing groups in situ generated from aromatic aldehydes and β-alanine could enable the subsequent C–H activation and hydroarylation with excellent sit...

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Bibliographic Details
Published in:Organic letters 2019-06, Vol.21 (11), p.3959-3962
Main Authors: Guan, Zhe, Chen, Siwei, Huang, Yue, Yao, Hequan
Format: Article
Language:English
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Summary:A Rh­(III)-catalyzed intramolecular olefin hydroarylation of aromatic aldehydes with a transient directing group has been described. The bidentate directing groups in situ generated from aromatic aldehydes and β-alanine could enable the subsequent C–H activation and hydroarylation with excellent site selectivities and high functional group compatibility. The further conversion of the aldehyde group showcased the broad application prospects of this methodology.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01101