Nanocarrier-based systems for wound healing

• Published in: Drug development and industrial pharmacy 2019-09, Vol.45 (9), p.1389-1402
• Main Authors: Bernal-Chávez, S., Nava-Arzaluz, M. G., Quiroz-Segoviano, R. I. Y., Ganem-Rondero, A.
• Format: Article
• Language: English
• Subjects: Chronic wounds; Dermatologic Agents - administration & dosage; Drug Carriers - chemistry; drug delivery system; Humans; nanocarriers; Nanocomposites - chemistry; nanotechnology; skin regeneration; wound healing; Wound Healing - drug effects
• ISSN: 0363-9045; 1520-5762
• DOI: 10.1080/03639045.2019.1620270

In general, the systems intended for the treatment and recovery of wounds, seek to act as a coating for the damaged area, maintaining an adequate level of humidity, reducing pain, and preventing the invasion and proliferation of microorganisms. Although many of the systems that are currently on the market meet the purposes mentioned above, with the arrival of nanotechnology, it has sought to improve the performance of these coatings. The variety of nano-systems that have been proposed is very extensive, including the use of very different materials (natural or synthetic) ranging from polymers or lipids to systems derived from microorganisms. With the objective of improving the performance of the systems, seeking to combat several of the problems that arise in a wound, especially when it is chronic, these materials have been combined, giving rise to nanocomposites or scaffolds. In recent years, the interest in the development of systems for the treatment of wounds is notable, which is reflected in the increase in publications related to the subject. Therefore, this document presents generalities of systems involving nanocarriers, mentioning some examples of representative systems of each case.