Prognosis after pacemaker implantation in extreme elderly

Significant comorbidities may limit the potential benefit of pacemaker (PM) implantation in extreme elderly. A short-term mortality risk prediction score, able to identify high-risk patients, may be a useful tool in this population. We retrospectively analyzed 538 patients aged >80 years at the t...

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Published in:European journal of internal medicine 2019-07, Vol.65, p.37-43
Main Authors: Balla, Cristina, Malagu’, Michele, Fabbian, Fabio, Guarino, Matteo, Zaraket, Fatima, Brieda, Alessandro, Smarrazzo, Vittorio, Ferrari, Roberto, Bertini, Matteo
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Language:English
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Complications
Geriatrics
Mortality
Pacemaker
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cited_by cdi_FETCH-LOGICAL-c356t-8b4f4a4ba9f03a854e9ab15ba42790df9c37a899b59003a607486a84d07b1aea3
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container_title European journal of internal medicine
container_volume 65
creator Balla, Cristina
Malagu’, Michele
Fabbian, Fabio
Guarino, Matteo
Zaraket, Fatima
Brieda, Alessandro
Smarrazzo, Vittorio
Ferrari, Roberto
Bertini, Matteo
description Significant comorbidities may limit the potential benefit of pacemaker (PM) implantation in extreme elderly. A short-term mortality risk prediction score, able to identify high-risk patients, may be a useful tool in this population. We retrospectively analyzed 538 patients aged >80 years at the time of implant who underwent PM implantation. Kaplan-Meier survival and multivariable Cox regression analyses were performed to identify patient, procedural or complication variables predictive of death. The ACP (Aging in Cardiac Pacing) Score was constructed by assigning weighted values to the variables identified by hazard ratios, combined into an additive mortality risk score equation. One, two and three-year overall mortality rate was 11%, 21% and 32% respectively. Renal failure (HR 1.63; CI 1.15–2.31; p = .006), active neoplasia (HR 1.78; CI 1.27–2.51; p = .008), connective tissue disorder (3.07; CI 1.34–7.08; p = .048), cerebrovascular disease (HR 1.75; CI 1.25–2.46; p = .001) and the use of a single lead device (HR 2.27; CI 1.6–3.24; p 
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A short-term mortality risk prediction score, able to identify high-risk patients, may be a useful tool in this population. We retrospectively analyzed 538 patients aged &gt;80 years at the time of implant who underwent PM implantation. Kaplan-Meier survival and multivariable Cox regression analyses were performed to identify patient, procedural or complication variables predictive of death. The ACP (Aging in Cardiac Pacing) Score was constructed by assigning weighted values to the variables identified by hazard ratios, combined into an additive mortality risk score equation. One, two and three-year overall mortality rate was 11%, 21% and 32% respectively. Renal failure (HR 1.63; CI 1.15–2.31; p = .006), active neoplasia (HR 1.78; CI 1.27–2.51; p = .008), connective tissue disorder (3.07; CI 1.34–7.08; p = .048), cerebrovascular disease (HR 1.75; CI 1.25–2.46; p = .001) and the use of a single lead device (HR 2.27; CI 1.6–3.24; p &lt; .001) were independently associated with worse survival. The ACP Score showed discrete predictive ability (AUC 0,6792 CI 0,63-0,73). Kaplan-Meier survival curves comparing low vs high ACP Scores demonstrated that low ACP scores were associated with reduced mortality rates (p &lt; .001). Significant comorbidities were associated with worse survival after PM implantation in extreme elderly. The ACP Score is a novel tool that may help to identify patients with high mortality risk after device implantation. •No impact of pre-implant clinical characteristics on PM complications' rates in extreme elderly.•Elderly comorbidities are predictors of mortality in octogenarians after PM implantation.•ACP Score helps to predict short-term mortality risk after PM implantation in extreme elderly.</description><identifier>ISSN: 0953-6205</identifier><identifier>EISSN: 1879-0828</identifier><identifier>DOI: 10.1016/j.ejim.2019.04.020</identifier><identifier>PMID: 31097259</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Complications ; Geriatrics ; Mortality ; Pacemaker</subject><ispartof>European journal of internal medicine, 2019-07, Vol.65, p.37-43</ispartof><rights>2019 European Federation of Internal Medicine</rights><rights>Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. 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Renal failure (HR 1.63; CI 1.15–2.31; p = .006), active neoplasia (HR 1.78; CI 1.27–2.51; p = .008), connective tissue disorder (3.07; CI 1.34–7.08; p = .048), cerebrovascular disease (HR 1.75; CI 1.25–2.46; p = .001) and the use of a single lead device (HR 2.27; CI 1.6–3.24; p &lt; .001) were independently associated with worse survival. The ACP Score showed discrete predictive ability (AUC 0,6792 CI 0,63-0,73). Kaplan-Meier survival curves comparing low vs high ACP Scores demonstrated that low ACP scores were associated with reduced mortality rates (p &lt; .001). Significant comorbidities were associated with worse survival after PM implantation in extreme elderly. 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A short-term mortality risk prediction score, able to identify high-risk patients, may be a useful tool in this population. We retrospectively analyzed 538 patients aged &gt;80 years at the time of implant who underwent PM implantation. Kaplan-Meier survival and multivariable Cox regression analyses were performed to identify patient, procedural or complication variables predictive of death. The ACP (Aging in Cardiac Pacing) Score was constructed by assigning weighted values to the variables identified by hazard ratios, combined into an additive mortality risk score equation. One, two and three-year overall mortality rate was 11%, 21% and 32% respectively. 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subjects Complications
Geriatrics
Mortality
Pacemaker
title Prognosis after pacemaker implantation in extreme elderly
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