Loss of β-arrestin-2 gene and possible functional consequences on Sezary Syndrome

Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present evidence also of the involvement of B-arrestin a downstream regulator of CXCR4, that is depleted and downregulated as well as a potential fu...

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Published in:Cell cycle (Georgetown, Tex.) Tex.), 2019-06, Vol.18 (11), p.1292-1294
Main Authors: Cristofoletti, Cristina, Bresin, Antonella, Caprini, Elisabetta, Russo, Giandomenico, Narducci, Maria Grazia
Format: Article
Language:English
Subjects:
B-arrestin
beta-Arrestin 2 - antagonists & inhibitors
beta-Arrestin 2 - genetics
beta-Arrestin 2 - physiology
Cells, Cultured
Cohort Studies
Copy Number Variation
CTCL
CXCR4-SDF-1
DNA Copy Number Variations
Gene Deletion
Gene Expression Regulation, Neoplastic - drug effects
Humans
Letter to the Editor
Leukemia/lymphoma
Lymphoma, T-Cell - genetics
Lymphoma, T-Cell - pathology
Neoplasm Invasiveness
Receptors, CXCR4 - genetics
RNA, Small Interfering - pharmacology
Sezary Syndrome - genetics
Sezary Syndrome - pathology
Skin Neoplasms - genetics
Skin Neoplasms - pathology
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Summary:Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present evidence also of the involvement of B-arrestin a downstream regulator of CXCR4, that is depleted and downregulated as well as a potential functional role for this depletion.
ISSN:1538-4101
1551-4005
1551-4005
DOI:10.1080/15384101.2019.1617007