Vaccine-derived varicella zoster infection in a kidney transplant recipient after zoster vaccine live administration

AbstractA 49-year-old kidney transplant recipient, presented with a skin rash, and interstitial infiltrates three weeks after receiving a live attenuated varicella-zoster vaccine. Varicella-zoster Oka-vaccine strain was detected in plasma by polymerase chain reaction and sequencing analysis targetin...

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Bibliographic Details
Published in:Vaccine 2019-06, Vol.37 (27), p.3576-3579
Main Authors: Ortiz-Brizuela, Edgar, Leal-Vega, Francisco, Cuellar-Rodríguez, Jennifer, Bobadilla-del-Valle, Miriam, Ponce-de-León, Alfredo
Format: Article
Language:English
Subjects:
Acyclovir
Allergy and Immunology
Blood
Chicken pox
Conflicts of interest
Family medical history
Herpes zoster
Immunization
Infections
Intravenous administration
Kidney transplantation
Kidney transplants
Kidneys
Open reading frames
Patients
Pneumonia
Polymerase chain reaction
Population
Shingles
Shingrix
Skin
Solid organ transplantation
Transplants & implants
Vaccines
Varicella
Zostavax
Zoster vaccine
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Summary:AbstractA 49-year-old kidney transplant recipient, presented with a skin rash, and interstitial infiltrates three weeks after receiving a live attenuated varicella-zoster vaccine. Varicella-zoster Oka-vaccine strain was detected in plasma by polymerase chain reaction and sequencing analysis targeting open reading frame 62 (ORF 62). She was treated successfully with intravenous acyclovir. Our case report supports the current contraindication of live attenuated varicella-zoster vaccine in the solid-organ transplant recipients. Recombinant subunit varicella-zoster vaccine may be the vaccine of choice in these patients; nevertheless, further information is required to establish its safety, efficacy, and optimal timing.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.05.017