The “Ice Age” in Cardiac Surgery: Evolution of the “Siberian” Method of Brain Protection During Deep Hypothermic Perfusionless Circulatory Arrest

Deep hypothermic perfusionless circulatory arrest was the first practical neuroprotective technique used for open-heart surgery. It was refined at the Novosibirsk Medical Research Center in Siberia and was actively used from the mid-1950s until 2001.This review describes the development of this tech...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2019-12, Vol.33 (12), p.3366-3374
Main Authors: Guvakov, Dmitri, Bezinover, Dmitri, Lomivorotov, Vladimir V., Postnov, Vadim G., Weiss, Stuart J., Cheung, Albert T., Swain, Julie, Lomivorotov, Vladimir N.
Format: Article
Language:English
Subjects:
cardio-pulmonary bypass
deep perfusion-less hypothermic circulatory arrest
hypothermic brain protection
hypothremic brain protection
luria battery
meshalkin clinic
neurocognitive evaluation
neuron-specific enolase
S-100-beta
surface body cooling for cardiac surgery
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Summary:Deep hypothermic perfusionless circulatory arrest was the first practical neuroprotective technique used for open-heart surgery. It was refined at the Novosibirsk Medical Research Center in Siberia and was actively used from the mid-1950s until 2001.This review describes the development of this technique and its contribution to our understanding of the dynamic changes in human physiology during induced hypothermia for circulatory arrest without extracorporeal perfusion. Deep hypothermic perfusionless circulatory arrest was an important stepping stone in the development of modern approaches in neuroprotection and monitoring during cardiac surgery.
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2019.04.001