Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.

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Bibliographic Details
Published in:Organic letters 2019-06, Vol.21 (11), p.3882-3885
Main Authors: Hurst, Timothy E, Deichert, Julie A, Kapeniak, Lucas, Lee, Roland, Harris, Jesse, Jessop, Philip G, Snieckus, Victor
Format: Article
Language:English
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Description
Summary:Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00773