Mouse models of neurodegeneration: Know your question, know your mouse

Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegener...

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Bibliographic Details
Published in:Science translational medicine 2019-05, Vol.11 (493)
Main Authors: Fisher, Elizabeth M C, Bannerman, David M
Format: Article
Language:English
Subjects:
Animal models
Animals
Circadian Rhythm
Disease Models, Animal
Humans
Mice
Microbiota
Mutation - genetics
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - pathology
Translational Medical Research
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Summary:Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegenerative disease mechanisms and emphasize the importance of asking appropriate research questions. In therapeutic studies, we suggest that understanding variability among and within mouse models is crucial for preventing translational failures in human patients.
ISSN:1946-6234
1946-6242
1946-3242
DOI:10.1126/scitranslmed.aaq1818