Detection of serum anti-retinal antibodies in the Chinese patients with presumed autoimmune retinopathy

Purpose To explore the presence of serum anti-retinal antibodies (ARAs) in the Chinese patients with presumed autoimmune retinopathy (AIR). Methods Twenty-three Chinese patients with presumed AIR, disease controls including 40 RP patients, 22 bilateral uveitis patients, 18 acute zonal outer occult r...

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Published in:Graefe's archive for clinical and experimental ophthalmology 2019-08, Vol.257 (8), p.1759-1764
Main Authors: Zeng, Hui-yang, Liu, Qian, Peng, Xiao-yan, Cao, Kai, Jin, Shan-shan, Xu, Ke
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies
Autoantibodies - blood
Autoimmune Diseases - blood
Autoimmune Diseases - epidemiology
Autoimmune Diseases - immunology
Blotting, Western
Carbonic Anhydrase II - blood
Carbonic Anhydrase II - immunology
Carbonic anhydrases
China - epidemiology
Disease control
Female
Humans
Incidence
Inflammatory Disorders
Male
Medicine
Medicine & Public Health
Middle Aged
Nerve Tissue Proteins - blood
Nerve Tissue Proteins - immunology
Ophthalmology
Phosphopyruvate hydratase
Phosphopyruvate Hydratase - blood
Phosphopyruvate Hydratase - immunology
Prevalence
Recoverin
Recoverin - blood
Recoverin - immunology
Retina
Retina - immunology
Retinal Diseases - blood
Retinal Diseases - epidemiology
Retinal Diseases - immunology
Retinopathy
Retrospective Studies
Uveitis
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Summary:Purpose To explore the presence of serum anti-retinal antibodies (ARAs) in the Chinese patients with presumed autoimmune retinopathy (AIR). Methods Twenty-three Chinese patients with presumed AIR, disease controls including 40 RP patients, 22 bilateral uveitis patients, 18 acute zonal outer occult retinopathy (AZOOR) patients, and 30 healthy donors were included. Serum samples of all the subjects were obtained and analyzed for the presence of four ARAs including recoverin, α-enolase, carbonic anhydraseII (CAII), and collapsin response-mediated protein (CRMP)-5 by Western bolt assay. Results ARAs were present in the serum of either presumed AIR patients, disease control, or healthy donors. One or more ARAs were present in the 78.2% of presumed AIR while they were indicated in the 35.0% of RP patients ( p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-019-04359-2