A Comparative Solubility Enhancement Study of Cefixime Trihydrate Using Different Dispersion Techniques

This study aimed to investigate the effect of different polymers (polyethylene glycol 4000 and 6000 and Soluplus®) on the enhancement of solubility, dissolution, and stability of cefixime trihydrate as a selected class II model drug. Different solid dispersions have been prepared using conventional...

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Bibliographic Details
Published in:AAPS PharmSciTech 2019-07, Vol.20 (5), p.194-194, Article 194
Main Authors: Obaidat, Rana M., Khanfar, Mai, Ghanma, Rand
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Calorimetry, Differential Scanning - methods
Cefixime - analysis
Cefixime - chemistry
Chromatography, Supercritical Fluid - methods
Pharmacology/Toxicology
Pharmacy
Polyethylene Glycols - analysis
Polyethylene Glycols - chemistry
Polyvinyls - analysis
Polyvinyls - chemistry
Research Article
Solubility
Spectroscopy, Fourier Transform Infrared - methods
X-Ray Diffraction
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Summary:This study aimed to investigate the effect of different polymers (polyethylene glycol 4000 and 6000 and Soluplus®) on the enhancement of solubility, dissolution, and stability of cefixime trihydrate as a selected class II model drug. Different solid dispersions have been prepared using conventional methods and supercritical fluid technology. The effect of co-solvent incorporation in supercritical fluid technology was also studied. Physicochemical properties for solid dispersions were investigated using Fourier transform infrared analysis, differential scanning calorimetry, thermogravimetric analysis, powder X-ray diffraction, and scanning electron microscopy. The solubility of the prepared solid dispersions increased except for those prepared with Soluplus® using supercritical fluid technology without co-solvent. The best enhancement in the release profile was recorded by Soluplus®-based solid dispersions prepared using a conventional method. The conventional methods of preparation and the presence of co-solvent in supercritical fluid technology converted cefixime into its amorphous form.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-019-1395-y