Association between exhaled nitric oxide and nasal polyposis in severe asthma

Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis. We investigated the potential association between FeNO and the presence of...

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Bibliographic Details
Published in:Respiratory medicine 2019-06, Vol.152, p.20-24
Main Authors: Maniscalco, Mauro, Calabrese, Cecilia, D'Amato, Maria, Guida, Pietro, Molino, Antonio, Aliani, Maria, De Tullio, Renato, Foschino Barbaro, Mariapia, Ricciardolo, Fabio Luigi Massimo, Carpagnano, Giovanna Elisiana
Format: Article
Language:English
Subjects:
Age
Aged
Asthma
Asthma - diagnosis
Asthma - drug therapy
Asthma - metabolism
Asthma - physiopathology
Biomarkers
Biomarkers - metabolism
Blood
Body mass
Breath
Computed tomography
Disability
Eosinophils
Exhalation
Exhaled
Family medical history
Female
Genotype & phenotype
Humans
Immunoglobulins
Inflammation
Italy - epidemiology
Leukocytes (eosinophilic)
Low level
Lung
Lung - physiopathology
Lungs
Male
Middle Aged
Nasal Polyps - complications
Nasal Polyps - epidemiology
Neutrophils
Nitric oxide
Nitric Oxide - analysis
Nose
Paranasal sinuses
Paranasal Sinuses - diagnostic imaging
Paranasal Sinuses - pathology
Polyposis
Polyps
Population studies
Respiratory function
Respiratory Function Tests - methods
Severity of Illness Index
Sinuses
Tomography, X-Ray Computed - methods
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Summary:Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis. We investigated the potential association between FeNO and the presence of nasal polyps in patients affected by severe asthma. Study population included 93 severe asthmatic adult patients consecutively enrolled from four Italian specialist clinic centres from 2015 to 2018. In these patients lung function, asthma control, FeNO, blood eosinophils and CT scan of paranasal sinuses were evaluated. Nasal polyposis was observed in 28 patients (30%). Among univariate predictors (lower BMI, higher FeNO, eosinophil and neutrophil count), recursive partitioning analysis identified as best predictors of nasal polyposis high values of eosinophil count (≥6.5% or >420 cells/mm3) and FeNO (≥39 ppb). The 40 patients with low eosinophil count and FeNO had a significant lower occurrence of nasal polyposis than those with higher values (8% vs 58%; p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2019.04.017