Clinical background and outcomes of risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancers in Japan

Background This study aimed to identify the clinical background and treatment outcomes of risk-reducing salpingo-oophorectomy (RRSO) in Japan for women with hereditary breast and ovarian cancer (HBOC). Methods In the present retrospective observational study, we examined the Japanese HBOC Consortium...

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Bibliographic Details
Published in:International journal of clinical oncology 2019-09, Vol.24 (9), p.1105-1110
Main Authors: Nomura, Hidetaka, Sekine, Masayuki, Yokoyama, Shiro, Arai, Masami, Enomoto, Takayuki, Takeshima, Nobuhiro, Nakamura, Seigo
Format: Article
Language:English
Subjects:
BRCA1 protein
BRCA2 protein
Breast cancer
Cancer Research
Gastric cancer
Genetic screening
Heredity
Medicine
Medicine & Public Health
Menopause
Mutation
Oncology
Original Article
Ovarian cancer
Ovariectomy
Patients
Peritoneum
Surgical Oncology
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Summary:Background This study aimed to identify the clinical background and treatment outcomes of risk-reducing salpingo-oophorectomy (RRSO) in Japan for women with hereditary breast and ovarian cancer (HBOC). Methods In the present retrospective observational study, we examined the Japanese HBOC Consortium’s (JHC) database. This database contains 11,711 probands who received BRCA genetic testing, or their relatives, with any cancer in 2433 pedigrees. This study was supported by the registration committee of the JHC. Results We analyzed 488 individuals diagnosed with HBOC, of which 153 (31.4%) underwent RRSO. Of the latter patients, 88 carried BRCA1 mutation (B1); 62 carried BRCA2 mutation (B2); and 3 carried both mutations. During a mean follow-up period of 2.6 years (range 0–12.6), one patient developed a primary peritoneal cancer (PPC). Clinical background comparison for individuals who underwent RRSO vs. those > 45 years of age who did not undergo RRSO revealed that significant factors were represented by B1 ( p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-019-01456-4