Cytarabine ears – A side effect of cytarabine therapy

Cytarabine, a pyramidine analog, is used for treating various hematological malignancies such as acute leukemias and lymphomas. Side effects of cytarabine are dose dependent and include bone marrow suppression, fever, cerebellar toxicity, cardiomyopathy, hepato-renal insufficiency, necrotizing enter...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice 2020-03, Vol.26 (2), p.471-473
Main Authors: Doval, Divya, Kumar Sharma, Sanjeev, Kumar, Meet, Khandelwal, Vipin, Choudhary, Dharma
Format: Article
Language:English
Subjects:
Bone marrow
Cardiomyopathy
Cerebellum
Cornea
Cytarabine
Cytokines
Ear
Enterocolitis
Fever
Hypersensitivity (delayed)
Lymphoma
Myelosuppression
Necrotizing enterocolitis
Pancreatitis
Renal insufficiency
Side effects
Toxicity
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Summary:Cytarabine, a pyramidine analog, is used for treating various hematological malignancies such as acute leukemias and lymphomas. Side effects of cytarabine are dose dependent and include bone marrow suppression, fever, cerebellar toxicity, cardiomyopathy, hepato-renal insufficiency, necrotizing enterocolitis, pancreatitis, acute respiratory distress, corneal toxicity and dermatological side effects. The dermatological side effects can be immediate or due to delayed hypersensitivity reactions. They have been attributed largely to release of cytokines. We present three such cases of delayed hypersensitivity to cytarabine affecting the ears bilaterally.
ISSN:1078-1552
1477-092X
DOI:10.1177/1078155219848800