Visible Light-Promoted Aliphatic C–H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent

A mild, practical method for direct arylation of unactivated C­(sp3)–H bonds with heteroarenes has been achieved via photochemistry. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation. A diverse range of chemical feedstocks, such as alkanes, ketones, esters, and...

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Bibliographic Details
Published in:Organic letters 2019-08, Vol.21 (16), p.6179-6184
Main Authors: Zhao, Hong, Jin, Jian
Format: Article
Language:English
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Summary:A mild, practical method for direct arylation of unactivated C­(sp3)–H bonds with heteroarenes has been achieved via photochemistry. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation. A diverse range of chemical feedstocks, such as alkanes, ketones, esters, and ethers, and complex molecules readily undergo intermolecular C­(sp3)–C­(sp2) bond formation. Moreover, a broad array of heteroarenes, including pharmaceutically useful scaffolds, can be alkylated effectively by the protocol presented here.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01635