Tag-Team Genetics of Spinocerebellar Ataxia 6

In this issue of Neuron, Du et al. (2019) demonstrate that the bicistronic CACNA1A gene encodes a transcription factor α1ACT, mutations in which are associated with SCA6, that controls expression of genes important for cerebellar Purkinje cell development and excitability. Reduction of α1ACT in the...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2019-05, Vol.102 (4), p.707-709
Main Authors: Govek, Eve-Ellen, Hatten, Mary E.
Format: Article
Language:English
Subjects:
Adult
Ataxia
CACNA1A protein
Calcium Channels
Cerebellum
Defects
Deoxyribonucleic acid
Disease
DNA
Excitability
Gene expression
Gene Expression Regulation
Humans
Infant, Newborn
Mutation
Proteins
Purkinje Cells
Spinocerebellar ataxia
Spinocerebellar Ataxias
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this issue of Neuron, Du et al. (2019) demonstrate that the bicistronic CACNA1A gene encodes a transcription factor α1ACT, mutations in which are associated with SCA6, that controls expression of genes important for cerebellar Purkinje cell development and excitability. Reduction of α1ACT in the adult is well tolerated, suggesting a potential new therapy for SCA6. In this issue of Neuron, Du et al. (2019) demonstrate that the bicistronic CACNA1A gene encodes a transcription factor α1ACT, mutations in which are associated with SCA6, that controls expression of genes important for cerebellar Purkinje cell development and excitability. Reduction of α1ACT in the adult is well tolerated, suggesting a potential new therapy for SCA6.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2019.04.041