Vaginal microbiome profiles of pregnant women in Korea using a 16S metagenomics approach

Problem The stability and dominance of Lactobacillus spp. in vaginal fluid are important for reproductive health. However, the characterization of the vaginal microbiota of women with preterm labor (PTL) or preterm premature rupture of membranes (P‐PROM), and its association with preterm birth (PTB)...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2019-07, Vol.82 (1), p.e13124-n/a
Main Authors: You, Young‐Ah, Kwon, Eun Jin, Choi, Suk‐Joo, Hwang, Han‐Sung, Choi, Sae‐Kyung, Lee, Seung Mi, Kim, Young Ju
Format: Article
Language:English
Subjects:
16S metagenomics
Abundance
Bacteroides
Classification
Lactobacillus
Microbiomes
Microbiota
Pregnancy
pregnant women
Premature birth
preterm birth
preterm labor
Reproductive health
rRNA 16S
Vagina
vaginal microbiome
Weissella
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Summary:Problem The stability and dominance of Lactobacillus spp. in vaginal fluid are important for reproductive health. However, the characterization of the vaginal microbiota of women with preterm labor (PTL) or preterm premature rupture of membranes (P‐PROM), and its association with preterm birth (PTB) are poorly understood. Method of study We collected vaginal fluid from women at risk of PTB (n = 58) in five university hospitals in Korea. We performed a hierarchical clustering analysis and classification according to the Lactobacillus spp. and Lactobacillus abundance using Illumina MiSeq sequencing of 16S rRNA gene amplicons. Results Women at risk for PTB caused by P‐PROM had greater bacterial richness and diversity at the time of admission than those with PTL (P 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.13124