AgNP combined with quorum sensing inhibitor increased the antibiofilm effect on Pseudomonas aeruginosa

Pseudomonas aeruginosa biofilm lifestyle exhibits multidrug resistance in chronic bacterial infections. Alternative antimicrobial compounds or combination drug therapies must be urgently developed. In this work, the antibiofilm effect of Ag nanoparticle (AgNP) combined with the quorum sensing inhibi...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2019-08, Vol.103 (15), p.6195-6204
Main Authors: Liu, Lei, Li, Jing-Hui, Zi, Shuang-Feng, Liu, Fu-Rong, Deng, Chao, Ao, Xue, Zhang, Peng
Format: Article
Language:English
Subjects:
Analysis
Antiinfectives and antibacterials
Antimicrobial agents
Applied Microbial and Cell Physiology
Bacteria
Bacterial diseases
Bacterial infections
Biofilms
Biomedical and Life Sciences
Biotechnology
Drug resistance in microorganisms
Drug therapy
Drug therapy, Combination
Exopolysaccharides
Flagella
Gene expression
Genes
Health aspects
Inhibitors
Life Sciences
Microbial Genetics and Genomics
Microbiology
Multidrug resistance
Nanoparticles
Pharmaceutical industry
Polysaccharides
Proteins
Pseudomonas aeruginosa
Quorum sensing
Saccharides
Silver
Swimming
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Summary:Pseudomonas aeruginosa biofilm lifestyle exhibits multidrug resistance in chronic bacterial infections. Alternative antimicrobial compounds or combination drug therapies must be urgently developed. In this work, the antibiofilm effect of Ag nanoparticle (AgNP) combined with the quorum sensing inhibitor (QSI) 4-nitropyridine N-oxide (4NPO) on P. aeruginosa biofilms was investigated. The biofilm biomass of P. aeruginosa was considerably reduced by 1.56–50 mg/L AgNP. However, 4NPO enhanced the ability of AgNP to inhibit P. aeruginosa biofilm formation ( P  
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-019-09905-w