Location and pattern of non‐invasive keratographic tear film break‐up according to dry eye disease subtypes

Purpose To compare the non‐invasive keratographic tear film break‐up time (NIKBUT) and the location and pattern of non‐invasive keratographic tear film break‐up between normal group and each group of three dry eye disease (DED) subtypes. Methods We enrolled 55 normal subjects and 250 patients with D...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2019-12, Vol.97 (8), p.e1089-e1097
Main Authors: Kim, Jieun, Kim, Jung Yong, Seo, Kyoung Yul, Kim, Tae‐im, Chin, Hee Seung, Jung, Ji Won
Format: Article
Language:English
Subjects:
Adult
Aged
aqueous‐deficient dry eye disease
Cornea - diagnostic imaging
Cross-Sectional Studies
Diagnostic Techniques, Ophthalmological
Dry Eye Syndromes - diagnosis
Dry Eye Syndromes - metabolism
Eye
Eye diseases
Female
Fluorescein
Humans
keratograph
Male
meibomian gland dysfunction
Meibomian Glands - metabolism
Meniscus
Middle Aged
non‐invasive keratographic tear film break‐up time
Reproducibility of Results
Tearing
Tears - metabolism
Young Adult
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Summary:Purpose To compare the non‐invasive keratographic tear film break‐up time (NIKBUT) and the location and pattern of non‐invasive keratographic tear film break‐up between normal group and each group of three dry eye disease (DED) subtypes. Methods We enrolled 55 normal subjects and 250 patients with DED, who underwent tear meniscus height and NIKBUT measurements using the Keratograph® 5M. Ocular surface parameter assessments such as the fluorescein tear break‐up time, ocular surface staining, Schirmer's test, and lid margin and meibomian gland examinations were performed, and the ocular surface disease index was determined. These parameters, including the proportion of the first tear film break‐up location and simultaneous multiple tear film break‐up pattern, were compared amongst the normal and DED subtypes. Results Aqueous‐deficient dry eye disease (ADDE) and ADDE/meibomian gland dysfunction (MGD) subtypes showed lower NIKBUTs than those of the normal group, whilst NIKBUTs of the MGD subtype did not differ from those of the normal group. The NIKBUTs showed a good diagnostic ability in diagnosing dry eye except MGD only. The occurrence of the first tear film break‐up in the central location was significantly higher in both the ADDE and ADDE/MGD subtypes, comprising approximately 40% in both subtypes (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.14129