Treatment of resistant visceral leishmaniasis with interferon gamma in combination with liposomal amphotericin B and allopurinol

This report describes the first case of visceral leishmaniasis (VL) resistant to pentavalent antimonials and also the first use of combinational therapy in Iran. The patient was a two-year old boy, from a non-endemic area for leishmaniasis in northern Iran, presenting with pentavalent antimonial res...

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Bibliographic Details
Published in:Parasitology international 2019-10, Vol.72, p.101934-101934, Article 101934
Main Authors: Khodabandeh, Mahmoud, Rostami, Ali, Borhani, Katayoun, Gamble, H. Ray, Mohammadi, Mohsen
Format: Article
Language:English
Subjects:
Amphotericin B
Interferon gamma
Iran
Resistant
Visceral leishmaniasis
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Summary:This report describes the first case of visceral leishmaniasis (VL) resistant to pentavalent antimonials and also the first use of combinational therapy in Iran. The patient was a two-year old boy, from a non-endemic area for leishmaniasis in northern Iran, presenting with pentavalent antimonial resistant VL. Additional treatment with conventional and liposomal amphotericin B was not effective. A complete cure was achieved following a three week treatment with liposomal amphotericin B (5 mg/kg/day for 5 days, then on the 14th and 21st days), allopurinol (25 mg/day for 5 days, then on the 14th and 21st days) and interferon gamma (50 μg/m2 subcutaneously three times weekly). Our results suggest a need for further studies to identify resistant Leishmania species and their susceptibility to different treatment regimens.
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2019.101934