Successful long-term antibiotic suppressive therapy in a case of prosthetic valve endocarditis and a case of extensive aortic and subclavian graft infection

Introduction The indication for surgical valve replacement in cases of infective endocarditis is well defined in current guidelines. However, some patients are not fit or willing to undergo major surgical procedures. Interestingly, to the best of our knowledge, there is scarce information in the lit...

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Bibliographic Details
Published in:Infection 2020-02, Vol.48 (1), p.133-136
Main Authors: Lechner, Arno M., Pretsch, Ingrid, Hoppe, Uta, Seitelberger, Rainald, Dinges, Christian
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Aorta
Aorta - microbiology
Blood Vessel Prosthesis - adverse effects
Blood Vessel Prosthesis - microbiology
Case Report
Case reports
Endocarditis
Endocarditis, Bacterial - drug therapy
Endocarditis, Bacterial - microbiology
Family Medicine
Female
General Practice
Heart Valve Prosthesis - adverse effects
Heart Valve Prosthesis - microbiology
Humans
Indication
Infectious Diseases
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Prostheses
Prosthesis-Related Infections - drug therapy
Prosthesis-Related Infections - microbiology
Subclavian Artery - microbiology
Therapy
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Summary:Introduction The indication for surgical valve replacement in cases of infective endocarditis is well defined in current guidelines. However, some patients are not fit or willing to undergo major surgical procedures. Interestingly, to the best of our knowledge, there is scarce information in the literature on how to deal with such cases and what might be the outcome. Case report We present two complicated cases of prosthetic infective endocarditis with definite indication for replacement of involved foreign material, who were treated successfully with long-term suppressive antibiotic therapy. Conclusion These two cases demonstrate that individualized long-term antibiotic suppressive therapy might be effective in selected patients with complicated PVE unfit or unwilling to undergo high-risk cardiothoracic surgical interventions.
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-019-01321-6