Cascade [1,5]-Hydride Transfer/Cyclization for Synthesis of [3,4]-Fused Oxindoles

The scandium-catalyzed redox-neutral cascade [1,5]-hydride transfer/cyclization between C4-amine-substituted isatins and 1,3-dicarbonyl compounds has been developed. This protocol enabled the synthesis of tricyclic [3,4]-fused oxindoles in good to high yields and excellent diastereoselectivities, fe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2019-07, Vol.84 (13), p.8440-8448
Main Authors: Zhu, Shuai, Chen, Chunqi, Duan, Kang, Sun, Yun-Ming, Li, Shuai-Shuai, Liu, Qing, Xiao, Jian
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The scandium-catalyzed redox-neutral cascade [1,5]-hydride transfer/cyclization between C4-amine-substituted isatins and 1,3-dicarbonyl compounds has been developed. This protocol enabled the synthesis of tricyclic [3,4]-fused oxindoles in good to high yields and excellent diastereoselectivities, featuring high atom- and step economy as well as good functional group tolerance.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b00489