Tectorigenin reduces type IV pilus-dependent cell adherence in Clostridium perfringens

Abstract Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans and animals around the globe. The type IV pilus (TFP) system plays a key role in the colonization and invasion of host cells, biofilm formation and gliding motility, which is vital for...

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Bibliographic Details
Published in:FEMS microbiology letters 2019-05, Vol.366 (10)
Main Authors: Liu, Shui, Wang, Jianfeng, Zhang, Jian, Wang, Tingting, Zhou, Yonglin, Lv, Qianghua, Hu, Naiyu, Shen, Xue, Deng, Xuming
Format: Article
Language:English
Subjects:
Antibacterial activity
Aquatic plants
Biofilms
Cell adhesion
Clostridium perfringens
Colonization
Gliding
Infections
Isoflavones
Microbiology
Motility
Rhizomes
Virulence
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Summary:Abstract Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans and animals around the globe. The type IV pilus (TFP) system plays a key role in the colonization and invasion of host cells, biofilm formation and gliding motility, which is vital for C. perfringens infection. Therefore, targeting TFP function may be a promising strategy for the treatment of C. perfringens infection. Here, we investigated the potential inhibitory effects of tectorigenin (TE), an isoflavone extracted from the rhizome of the Chinese herb Belamcanda chinensis (L.) DC, on gliding motility, biofilm formation, adherence to cells and antibacterial activity of C. perfringens. Tectorigenin significantly inhibited gliding motility, biofilm formation and adherence to Caco-2 cells without observable antibacterial activity against C. perfringens. In addition, we also demonstrated that the inhibitory effect of TE on TFP function appears to be partially achieved by the suppression of TFP-associated genes. These findings demonstrate that TE may have the potential to be developed as a new anti-virulence drug for C. perfringens infection, particularly for the targeting of TFP. Identification of a novel natural compound against the function of type IV pilus-dependent virulence in Clostridium perfringens.
ISSN:1574-6968
0378-1097
1574-6968
DOI:10.1093/femsle/fnz112