Serum Glucose and Potassium Ratio as Risk Factors for Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

• Published in: Journal of stroke and cerebrovascular diseases 2019-07, Vol.28 (7), p.1951-1957
• Main Authors: Matano, Fumihiro, Fujiki, Yu, Mizunari, Takayuki, Koketsu, Kenta, Tamaki, Tomonori, Murai, Yasuo, Yokota, Hiroyuki, Morita, Akio
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aneurysmal subarachnoid hemorrhage; biomarker; Biomarkers - blood; Blood Glucose - analysis; Cerebral Angiography; Cerebral Infarction - blood; Cerebral Infarction - diagnostic imaging; Cerebral Infarction - etiology; cerebral vasospasm; Female; glucose; Humans; Male; Middle Aged; potassium; Potassium - blood; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Subarachnoid Hemorrhage - blood; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - diagnosis; Vasospasm, Intracranial - blood; Vasospasm, Intracranial - diagnostic imaging; Vasospasm, Intracranial - etiology; Young Adult
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.041

Objective: Cerebral vasospasm is associated with poor prognosis in patients with aneurysmal subarachnoid hemorrhage (SAH), and biomarkers for predicting poor prognosis have not yet been established. We attempted to clarify the relationship between serum glucose/potassium ratio and cerebral vasospasm in patients with aneurysmal SAH. Methods: We studied 333 of 535 aneurysmal SAH patients treated between 2006 and 2016 (123 males, 210 females; mean age 59.7 years; range 24-93). We retrospectively analyzed the relationship between cerebral vasospasm grade and clinical risk factors, including serum glucose/potassium ratio. Results: Postoperative angiography revealed cerebral vasospasm in 112 patients (33.6%). Significant correlations existed between the ischemic complication due to cerebral vasospasm and glucose/potassium ratio (P < .0001), glucose (P = .016), and potassium (P = .0017). Serum glucose/potassium ratio was elevated in the cerebral vasospasm grade dependent manner (Spearman's r = 0.1207, P = .0279). According to the Glasgow Outcome Scale (GOS) score at discharge, 185 patients (55.5%) had a poor outcome (GOS scores 1-3). Serum glucose/potassium ratio was significantly correlated between poor outcome (GOS scores 1-3) and age (P < .0001), serum glucose/potassium ratio (P < .0001), glucose (P < .0001), potassium (P = .0004), white blood cell count (P = .0012), and cerebral infarction due to cerebral vasospasm (P < .0001). Multivariate logistic regression analyzes showed significant correlations between cerebral infarction due to cerebral vasospasm and serum glucose/potassium ratio (P = .018), glucose (P = .027), and potassium (P = .052). Conclusions: Serum glucose/potassium ratio in cases of aneurysmal SAH was significantly associated with cerebral infarction due to cerebral vasospasm and GOS at discharge. Therefore, this factor was useful to predict prognosis in patients with cerebral vasospasm and aneurysmal SAH.