STREPTOZOTOCIN-INDUCED DIABETES MELLITUS - A PARADOX OF HIGH INTRINSIC PLATELET REACTIVITY AND LOW IN VITRO PLATELET AGGREGATION

Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change. We aimed to evaluate platelet indices and platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus. Twelve controls and 14 diabetic rats we...

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Published in:Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2019-01, Vol.5 (1), p.46-51
Main Authors: Scridon, A, Perian, M, Mărginean, A, Vântu, A, Gherţescu, D, Fişcă, C, Halatiu, V, Grigoras, T, Şerban, R C
Format: Article
Language:English
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Summary:Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change. We aimed to evaluate platelet indices and platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus. Twelve controls and 14 diabetic rats were investigated. Diabetes was induced in 11-week-old rats using streptozotocin (60 mg/kg,i.p.). Platelet indices and adenosine diphosphate (ADP)-, protease-activated receptor 4 (PAR4) agonist-, and arachidonic acid (AA)-induced platelet aggregation were assessed at the age of 38 weeks. Compared to controls, diabetic rats presented lower platelet count and plateletcrit (both p≤0.001), and higher mean platelet volume (p
ISSN:1841-0987
1843-066X
DOI:10.4183/aeb.2019.46