Loading…

Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management

Prognostic scores help in predicting mortality and functional outcome post intracerebral hemorrhage (ICH). We aimed to validate the ICH and ICH-GS scores in a cohort of Indian patients with ICH and observe the impact of any surgical intervention on prognostication. This was an ambispective observati...

Full description

Saved in:
Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2019-08, Vol.28 (8), p.2213-2220
Main Authors: U.M., Puneeth, Bhatia, Rohit, Sreenivas, Vishnubhatla, Singh, Nishita, Joseph, Rimpy, Dash, Deepa, Singh, Rajesh Kumar, Tripathi, Manjari, Srivastava, M.V. Padma, Singh, Man Mohan, Suri, Ashish, Prasad, Kameshwar
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83
cites cdi_FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83
container_end_page 2220
container_issue 8
container_start_page 2213
container_title Journal of stroke and cerebrovascular diseases
container_volume 28
creator U.M., Puneeth
Bhatia, Rohit
Sreenivas, Vishnubhatla
Singh, Nishita
Joseph, Rimpy
Dash, Deepa
Singh, Rajesh Kumar
Tripathi, Manjari
Srivastava, M.V. Padma
Singh, Man Mohan
Suri, Ashish
Prasad, Kameshwar
description Prognostic scores help in predicting mortality and functional outcome post intracerebral hemorrhage (ICH). We aimed to validate the ICH and ICH-GS scores in a cohort of Indian patients with ICH and observe the impact of any surgical intervention on prognostication. This was an ambispective observational study of primary ICH cases enrolled between January 2014 and April 2018. Observed mortality on ICH and ICH GS scores for the entire cohort and individually for the medically and surgically managed patients was compared to the published mortality in the original derivation cohorts. 617 patients, (464 retrospective and 153 prospective) of ICH were included. In hospital mortality and 30-day mortality was 28.7% and 28.5% respectively. There was a significant association of increasing mortality with increasing ICH and ICH-GS scores. Area under receiver operating characteristic curve for 30-day mortality was 75.9% and 74.1% for ICH and ICH-GS scores respectively. However, mortality observed at individual scores was significantly less than previously reported. Among the surgically intervened patients (n = 265), both the expected mortality at baseline and discriminative ability of ICH and ICH-GS scores for 30-day mortality was significantly reduced following surgical intervention (ROC in surgically intervened groups: 59.9 (52.6-67.2) and 63(56-70) for ICH and ICH-GS scores respectively). Although ICH and ICH-GS scores are valid in Indian population, mortality at individual scores is lower than previously reported. Mortality prediction using ICH and ICH GS scores is significantly modified by surgical interventions. Thus, newer prognostic tools which incorporate surgical intervention need to be developed and validated in future.
doi_str_mv 10.1016/j.jstrokecerebrovasdis.2019.05.003
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2233856312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S105230571930223X</els_id><sourcerecordid>2233856312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83</originalsourceid><addsrcrecordid>eNqVkM1OwzAQhC0EolB4BZQjQkpYx3XrcIOKn0pFHApcLdfeFJckLnZSibfHbYETF06ztmdn5I-QCwoZBTq8XGbL0Hr3jho9zr1bq2BsyHKgRQY8A2B75IhylqeCU7ofZ-B5yoCPeuQ4hCUApVzwQ9JjcaCCjY7I_FVV1qjWuiZxZTIZPySqMRtN72fJTDuPIbFNvEwmjbFRxu7N-fYqmdQrpdvN0iMaq1W1XZx1frE9PKpGLbDGpj0hB6WqAp5-a5-83N0-x4Lp0_1kfD1N9QAGbWoKrY0AUww5zblGxlR8MEAHKLiCohBKFwJRMRAcS6HEqOSimPNioEteCtYn57vclXcfHYZW1jZorCrVoOuCzHPGBB8ymkfrzc6qvQvBYylX3tbKf0oKcsNaLuVfrOWGtQQuI-sYcvbd181rNL8RP3CjYbozYPz12qKXQVtsdMTlUbfSOPufvi9ODp01</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2233856312</pqid></control><display><type>article</type><title>Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management</title><source>Elsevier</source><creator>U.M., Puneeth ; Bhatia, Rohit ; Sreenivas, Vishnubhatla ; Singh, Nishita ; Joseph, Rimpy ; Dash, Deepa ; Singh, Rajesh Kumar ; Tripathi, Manjari ; Srivastava, M.V. Padma ; Singh, Man Mohan ; Suri, Ashish ; Prasad, Kameshwar</creator><creatorcontrib>U.M., Puneeth ; Bhatia, Rohit ; Sreenivas, Vishnubhatla ; Singh, Nishita ; Joseph, Rimpy ; Dash, Deepa ; Singh, Rajesh Kumar ; Tripathi, Manjari ; Srivastava, M.V. Padma ; Singh, Man Mohan ; Suri, Ashish ; Prasad, Kameshwar</creatorcontrib><description>Prognostic scores help in predicting mortality and functional outcome post intracerebral hemorrhage (ICH). We aimed to validate the ICH and ICH-GS scores in a cohort of Indian patients with ICH and observe the impact of any surgical intervention on prognostication. This was an ambispective observational study of primary ICH cases enrolled between January 2014 and April 2018. Observed mortality on ICH and ICH GS scores for the entire cohort and individually for the medically and surgically managed patients was compared to the published mortality in the original derivation cohorts. 617 patients, (464 retrospective and 153 prospective) of ICH were included. In hospital mortality and 30-day mortality was 28.7% and 28.5% respectively. There was a significant association of increasing mortality with increasing ICH and ICH-GS scores. Area under receiver operating characteristic curve for 30-day mortality was 75.9% and 74.1% for ICH and ICH-GS scores respectively. However, mortality observed at individual scores was significantly less than previously reported. Among the surgically intervened patients (n = 265), both the expected mortality at baseline and discriminative ability of ICH and ICH-GS scores for 30-day mortality was significantly reduced following surgical intervention (ROC in surgically intervened groups: 59.9 (52.6-67.2) and 63(56-70) for ICH and ICH-GS scores respectively). Although ICH and ICH-GS scores are valid in Indian population, mortality at individual scores is lower than previously reported. Mortality prediction using ICH and ICH GS scores is significantly modified by surgical interventions. Thus, newer prognostic tools which incorporate surgical intervention need to be developed and validated in future.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2019.05.003</identifier><identifier>PMID: 31151837</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ICH GS score ; ICH score ; intracerebral hemorrhage ; prognostic scores</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2019-08, Vol.28 (8), p.2213-2220</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83</citedby><cites>FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83</cites><orcidid>0000-0001-7662-3202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31151837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>U.M., Puneeth</creatorcontrib><creatorcontrib>Bhatia, Rohit</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Singh, Nishita</creatorcontrib><creatorcontrib>Joseph, Rimpy</creatorcontrib><creatorcontrib>Dash, Deepa</creatorcontrib><creatorcontrib>Singh, Rajesh Kumar</creatorcontrib><creatorcontrib>Tripathi, Manjari</creatorcontrib><creatorcontrib>Srivastava, M.V. Padma</creatorcontrib><creatorcontrib>Singh, Man Mohan</creatorcontrib><creatorcontrib>Suri, Ashish</creatorcontrib><creatorcontrib>Prasad, Kameshwar</creatorcontrib><title>Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>Prognostic scores help in predicting mortality and functional outcome post intracerebral hemorrhage (ICH). We aimed to validate the ICH and ICH-GS scores in a cohort of Indian patients with ICH and observe the impact of any surgical intervention on prognostication. This was an ambispective observational study of primary ICH cases enrolled between January 2014 and April 2018. Observed mortality on ICH and ICH GS scores for the entire cohort and individually for the medically and surgically managed patients was compared to the published mortality in the original derivation cohorts. 617 patients, (464 retrospective and 153 prospective) of ICH were included. In hospital mortality and 30-day mortality was 28.7% and 28.5% respectively. There was a significant association of increasing mortality with increasing ICH and ICH-GS scores. Area under receiver operating characteristic curve for 30-day mortality was 75.9% and 74.1% for ICH and ICH-GS scores respectively. However, mortality observed at individual scores was significantly less than previously reported. Among the surgically intervened patients (n = 265), both the expected mortality at baseline and discriminative ability of ICH and ICH-GS scores for 30-day mortality was significantly reduced following surgical intervention (ROC in surgically intervened groups: 59.9 (52.6-67.2) and 63(56-70) for ICH and ICH-GS scores respectively). Although ICH and ICH-GS scores are valid in Indian population, mortality at individual scores is lower than previously reported. Mortality prediction using ICH and ICH GS scores is significantly modified by surgical interventions. Thus, newer prognostic tools which incorporate surgical intervention need to be developed and validated in future.</description><subject>ICH GS score</subject><subject>ICH score</subject><subject>intracerebral hemorrhage</subject><subject>prognostic scores</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqVkM1OwzAQhC0EolB4BZQjQkpYx3XrcIOKn0pFHApcLdfeFJckLnZSibfHbYETF06ztmdn5I-QCwoZBTq8XGbL0Hr3jho9zr1bq2BsyHKgRQY8A2B75IhylqeCU7ofZ-B5yoCPeuQ4hCUApVzwQ9JjcaCCjY7I_FVV1qjWuiZxZTIZPySqMRtN72fJTDuPIbFNvEwmjbFRxu7N-fYqmdQrpdvN0iMaq1W1XZx1frE9PKpGLbDGpj0hB6WqAp5-a5-83N0-x4Lp0_1kfD1N9QAGbWoKrY0AUww5zblGxlR8MEAHKLiCohBKFwJRMRAcS6HEqOSimPNioEteCtYn57vclXcfHYZW1jZorCrVoOuCzHPGBB8ymkfrzc6qvQvBYylX3tbKf0oKcsNaLuVfrOWGtQQuI-sYcvbd181rNL8RP3CjYbozYPz12qKXQVtsdMTlUbfSOPufvi9ODp01</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>U.M., Puneeth</creator><creator>Bhatia, Rohit</creator><creator>Sreenivas, Vishnubhatla</creator><creator>Singh, Nishita</creator><creator>Joseph, Rimpy</creator><creator>Dash, Deepa</creator><creator>Singh, Rajesh Kumar</creator><creator>Tripathi, Manjari</creator><creator>Srivastava, M.V. Padma</creator><creator>Singh, Man Mohan</creator><creator>Suri, Ashish</creator><creator>Prasad, Kameshwar</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7662-3202</orcidid></search><sort><creationdate>20190801</creationdate><title>Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management</title><author>U.M., Puneeth ; Bhatia, Rohit ; Sreenivas, Vishnubhatla ; Singh, Nishita ; Joseph, Rimpy ; Dash, Deepa ; Singh, Rajesh Kumar ; Tripathi, Manjari ; Srivastava, M.V. Padma ; Singh, Man Mohan ; Suri, Ashish ; Prasad, Kameshwar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>ICH GS score</topic><topic>ICH score</topic><topic>intracerebral hemorrhage</topic><topic>prognostic scores</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>U.M., Puneeth</creatorcontrib><creatorcontrib>Bhatia, Rohit</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Singh, Nishita</creatorcontrib><creatorcontrib>Joseph, Rimpy</creatorcontrib><creatorcontrib>Dash, Deepa</creatorcontrib><creatorcontrib>Singh, Rajesh Kumar</creatorcontrib><creatorcontrib>Tripathi, Manjari</creatorcontrib><creatorcontrib>Srivastava, M.V. Padma</creatorcontrib><creatorcontrib>Singh, Man Mohan</creatorcontrib><creatorcontrib>Suri, Ashish</creatorcontrib><creatorcontrib>Prasad, Kameshwar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>U.M., Puneeth</au><au>Bhatia, Rohit</au><au>Sreenivas, Vishnubhatla</au><au>Singh, Nishita</au><au>Joseph, Rimpy</au><au>Dash, Deepa</au><au>Singh, Rajesh Kumar</au><au>Tripathi, Manjari</au><au>Srivastava, M.V. Padma</au><au>Singh, Man Mohan</au><au>Suri, Ashish</au><au>Prasad, Kameshwar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>28</volume><issue>8</issue><spage>2213</spage><epage>2220</epage><pages>2213-2220</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>Prognostic scores help in predicting mortality and functional outcome post intracerebral hemorrhage (ICH). We aimed to validate the ICH and ICH-GS scores in a cohort of Indian patients with ICH and observe the impact of any surgical intervention on prognostication. This was an ambispective observational study of primary ICH cases enrolled between January 2014 and April 2018. Observed mortality on ICH and ICH GS scores for the entire cohort and individually for the medically and surgically managed patients was compared to the published mortality in the original derivation cohorts. 617 patients, (464 retrospective and 153 prospective) of ICH were included. In hospital mortality and 30-day mortality was 28.7% and 28.5% respectively. There was a significant association of increasing mortality with increasing ICH and ICH-GS scores. Area under receiver operating characteristic curve for 30-day mortality was 75.9% and 74.1% for ICH and ICH-GS scores respectively. However, mortality observed at individual scores was significantly less than previously reported. Among the surgically intervened patients (n = 265), both the expected mortality at baseline and discriminative ability of ICH and ICH-GS scores for 30-day mortality was significantly reduced following surgical intervention (ROC in surgically intervened groups: 59.9 (52.6-67.2) and 63(56-70) for ICH and ICH-GS scores respectively). Although ICH and ICH-GS scores are valid in Indian population, mortality at individual scores is lower than previously reported. Mortality prediction using ICH and ICH GS scores is significantly modified by surgical interventions. Thus, newer prognostic tools which incorporate surgical intervention need to be developed and validated in future.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31151837</pmid><doi>10.1016/j.jstrokecerebrovasdis.2019.05.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7662-3202</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1052-3057
ispartof Journal of stroke and cerebrovascular diseases, 2019-08, Vol.28 (8), p.2213-2220
issn 1052-3057
1532-8511
language eng
recordid cdi_proquest_miscellaneous_2233856312
source Elsevier
subjects ICH GS score
ICH score
intracerebral hemorrhage
prognostic scores
title Validation of ICH and ICH-GS Scores in an Indian Cohort: Impact of Medical and Surgical Management
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A32%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Validation%20of%20ICH%20and%20ICH-GS%20Scores%20in%20an%20Indian%20Cohort:%20Impact%20of%20Medical%20and%20Surgical%20Management&rft.jtitle=Journal%20of%20stroke%20and%20cerebrovascular%20diseases&rft.au=U.M.,%20Puneeth&rft.date=2019-08-01&rft.volume=28&rft.issue=8&rft.spage=2213&rft.epage=2220&rft.pages=2213-2220&rft.issn=1052-3057&rft.eissn=1532-8511&rft_id=info:doi/10.1016/j.jstrokecerebrovasdis.2019.05.003&rft_dat=%3Cproquest_cross%3E2233856312%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c404t-d9ccd80d965125ce33ac40d014e85a0998ac98eea3085ef8a87f589b594cf5f83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2233856312&rft_id=info:pmid/31151837&rfr_iscdi=true