Morphological and histopathological evaluation of autopsied patients with hypertensive cardiopathy

Physiopathological processes in hypertensive heart disease are controlled by complex interactions between cardiomyocytes, extracellular matrix, microvasculature and other cells present in the myocardium. To analyze morphological changes in hypertensive cardiopathy and to describe and compare finding...

Full description

Saved in:
Bibliographic Details
Published in:Annals of diagnostic pathology 2019-08, Vol.41, p.79-82
Main Authors: Juliano, Guilherme Ribeiro, Aguiar, Laura Sanches, dos Reis Monteiro, Maria Luíza Gonçalves, Alberto, Gustavo Branquinho, Torquato, Bianca Gonçalves Silva, Oliveira, Mariana Silva, dos Reis Félix, José Eduardo, de Araújo, Márcia Fernandes, Corrêa, Rosana Rosa Miranda, de Paula Antunes Teixeira, Vicente, da Fonseca Ferraz, Mara Lúcia
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Autopsy
Cross-Sectional Studies
Female
Heart Diseases - etiology
Heart Diseases - pathology
Humans
Hypertension - complications
Hypertensive Heart Disease
Male
Mast Cells
Middle Aged
Retrospective Studies
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Physiopathological processes in hypertensive heart disease are controlled by complex interactions between cardiomyocytes, extracellular matrix, microvasculature and other cells present in the myocardium. To analyze morphological changes in hypertensive cardiopathy and to describe and compare findings in order to help clarify determinant factors. 42 fragments of the left ventricular myocardium and circumflex branch of the left coronary artery were obtained from individuals autopsied at the Clinical Hospital of the Federal University of Triângulo Mineiro (UFTM) in the period ranging from 1984 to 2018. Groups were split into individuals with hypertensive heart disease (HD) and individuals without heart disease (ND). Wall thickness was measured with a digital caliper and Computed Tomography. Quantification of collagen fibers was conducted by computerized morphometry and mast cell density was assessed by immunohistochemical methods. There was a significant increase of heart weight in the HD group compared to the ND group, (p = 0.0002). There was a significant increase of thickness of the middle third of the free wall in the HD group compared to the ND group, (p = 0.04). There was a significant increase of collagen fibers in the left ventricle in the HD group compared to the ND group, (p 
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2019.04.012