Frequency and prognostic impact of acute kidney injury in patients with acute pulmonary embolism. Data from the RIETE registry

Acute kidney injury (AKI) is associated with a poor outcome. Although pulmonary embolism (PE) may promote AKI through renal congestion and/or hemodynamic instability, its frequency and influence on outcome in patients with acute PE have been poorly studied. The frequency of AKI (defined according to...

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Bibliographic Details
Published in:International journal of cardiology 2019-09, Vol.291, p.121-126
Main Authors: Murgier, Martin, Bertoletti, Laurent, Darmon, Michael, Zeni, Fabrice, Valle, Reina, Del Toro, Jorge, Llamas, Pilar, Mazzolai, Lucia, Villalobos, Aurora, Monreal, Manuel
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - diagnosis
Acute Kidney Injury - mortality
Aged
Aged, 80 and over
Biomarkers
Bleeding
Female
Humans
Internationality
Male
Middle Aged
Mortality
Mortality - trends
Multivariate Analysis
Prognosis
Prospective Studies
Pulmonary embolism
Pulmonary Embolism - diagnosis
Pulmonary Embolism - mortality
Registries
Risk
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Summary:Acute kidney injury (AKI) is associated with a poor outcome. Although pulmonary embolism (PE) may promote AKI through renal congestion and/or hemodynamic instability, its frequency and influence on outcome in patients with acute PE have been poorly studied. The frequency of AKI (defined according to the “Kidney Disease: Improving Global Outcomes” definition) at baseline and its influence on the 30-day mortality was evaluated in patients with acute PE from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry. We used multivariate analysis to assess whether the presence of AKI influenced the risk for 30-day death. The study included 21,131 patients, of whom 6222 (29.5%) had AKI at baseline: 4385 patients (21%) in stage 1, 1385 (6.5%) in stage 2 and 452 (2%) in stage 3. The proportion of patients with high-risk PE in those with no AKI, AKI stage 1, AKI stage 2 or AKI stage 3 was: 2.8%, 5.3%, 8.8% and 12%, respectively (p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2019.04.083