Association of circulating growth differentiation factor-15, Krüppel-like factor 4 and growth arrest-specific 6 with coronary artery disease

Current assessment tools for patients with acute chest pain are either traumatic (coronary angiography) or unreliable (measurement of cardiac troponin concentrations). We investigated whether the novel cardiovascular stress markers, serum growth differentiation factor-15 (GDF-15), Krüppel-like facto...

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Bibliographic Details
Published in:Clinica chimica acta 2019-08, Vol.495, p.630-636
Main Authors: Liu, Huan, Lyu, Yong-nan, Li, Di, Cui, Yan, Dai, Wen, Li, Yan
Format: Article
Language:English
Subjects:
Coronary artery disease
Gensini score
Growth arrest-specific 6
Growth differentiation factor-15
Krüppel-like factor 4
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Summary:Current assessment tools for patients with acute chest pain are either traumatic (coronary angiography) or unreliable (measurement of cardiac troponin concentrations). We investigated whether the novel cardiovascular stress markers, serum growth differentiation factor-15 (GDF-15), Krüppel-like factor 4 (KLF4) and growth arrest-specific 6 (gas6) may be useful biomarkers of coronary artery disease (CAD). A total of 350 male patients were enrolled, 198 with CAD and 152 controls, based on coronary angiography. GDF-15, KLF4 and gas6 concentrations were measured using commercial enzyme-linked immunosorbent assay kits. Multivariate logistic regression and multivariate linear regression were performed to evaluate potential associations of GDF-15, KLF4 and gas6 with risk of CAD or CAD severity. Serum GDF-15, KLF4 and gas6 concentrations were significantly higher in male patients with CAD than in control subjects (P 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2019.05.029