Successful treatment of refractory metastatic neuroblastoma with panobinostat in combination with chemotherapy agents and iodine-131-meta-iodobenzylguanidine therapy

Introduction Neuroblastoma commonly required multimodal therapy containing surgery, chemotherapy, radiotherapy, and immunotherapy. Case report In our case, who had refractory metastatic neuroblastoma, we use histone deacetylase inhibitor (panobinostat) in combination with chemotherapy agents and iod...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice 2020-03, Vol.26 (2), p.481-486
Main Authors: Zareifar, Soheila, Shakibazad, Nader, Zekavat, Omid Reza, Bordbar, Mohammadreza, Shahriari, Mahdi
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Apoptosis
Autografts
Bone marrow
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - drug therapy
Chemotherapy
Child
Combined Modality Therapy - methods
Female
Histone deacetylase
Histone Deacetylase Inhibitors - administration & dosage
Humans
Immunotherapy
Iodine
Iodine Radioisotopes - administration & dosage
Metastases
Metastasis
Neoplasms, Second Primary - diagnostic imaging
Neoplasms, Second Primary - therapy
Neuroblastoma
Neuroblastoma - diagnostic imaging
Neuroblastoma - drug therapy
Panobinostat - administration & dosage
Radiation therapy
Radiopharmaceuticals - administration & dosage
Stem Cell Transplantation - methods
Surgery
Transplantation
Transplantation, Autologous - methods
Treatment Outcome
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Summary:Introduction Neuroblastoma commonly required multimodal therapy containing surgery, chemotherapy, radiotherapy, and immunotherapy. Case report In our case, who had refractory metastatic neuroblastoma, we use histone deacetylase inhibitor (panobinostat) in combination with chemotherapy agents and iodine-131-meta-iodobenzylguanidine (MIBG) therapy. Management and outcome This approach leads to successfully treat the patient. MIBG scan and bone marrow examination after therapy revealed no evidence of tumor. Now, she underwent autologous transplantation six months ago and free of tumor. Conclusion Panobinostat can cause apoptosis induction in refractory metastatic neuroblastoma in combination with MIBG therapy and chemotherapy.
ISSN:1078-1552
1477-092X
DOI:10.1177/1078155219852670