Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)

Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development...

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Bibliographic Details
Published in:Chemosphere (Oxford) 2019-10, Vol.232, p.171-179
Main Authors: Qiu, Lingyu, Jia, Kun, Huang, Lirong, Liao, Xinjun, Guo, Xinchun, Lu, Huiqiang
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Apoptosis
Chemical and Drug Induced Liver Injury
Hepatotoxicity
Metabolism disorder
Oxidative Stress
Reactive Oxygen Species - metabolism
Thiazoles - toxicity
Tricyclazole
Water Pollutants, Chemical - toxicity
Zebrafish
Zebrafish - metabolism
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Summary:Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function. [Display omitted] •Tricyclazole induce hepatotoxicity in zebrafish.•Tricyclazole affected the liver development in zebrafish embryos.•Tricyclazole induced ROS and apoptosis in zebrafish liver.•Tricyclazole induced metabolism disturbance in zebrafish liver.
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2019.05.159