Intraarticular injection of a Tin‐117 m radiosynoviorthesis agent in normal canine elbows causes no adverse effects

• Published in: Veterinary radiology & ultrasound 2019-09, Vol.60 (5), p.567-574
• Main Authors: Lattimer, Jimmy C., Selting, Kimberly A., Lunceford, Joni M., Holland, James R., Simon, Jaime, Stevenson, Nigel R., Doerr, Cynthia A.
• Format: Article
• Language: English
• Subjects: Animals; arthritis; Dogs; Injections, Intra-Articular - veterinary; Isotopes - administration & dosage; Isotopes - adverse effects; Longitudinal Studies; Magnetic Resonance Imaging - veterinary; Positron-Emission Tomography - veterinary; Prospective Studies; radiation therapy; radioisotope; Radiopharmaceuticals - adverse effects; Reference Values; synovectomy; Tin - administration & dosage; Tin - adverse effects
• ISSN: 1058-8183; 1740-8261
• DOI: 10.1111/vru.12757

This longitudinal prospective exploratory study used serial measurements in five dogs to evaluate safety and retention of a tin‐117 m (117mSn) colloid after intra‐articular injection in normal elbow joints. Each dog was deemed healthy based on physical examination, laboratory results, and radiographic evaluation of both elbows. While anesthetized, each received an MRI of both elbows, followed by fluorine‐18 fluorodeoxyglucose positron emission tomography scans of both elbow joints and associated lymph nodes. Joint fluid (0.5‐1.0 mL) was withdrawn aseptically from the left elbow joint, followed by intra‐articular injection of 117mSn colloid (92.5 MBq; 1‐1.5 ml). Post‐injection assessments included blood counts, serum chemistry panels, urinalyses, radiographs, joint fluid analyses, MRI/positron emission tomography scans, scintigraphy, and biodistribution scans. On day 45‐47, each dog was euthanized and a complete postmortem examination was performed. Tissue samples were submitted for histopathology and radioisotope retention studies. Left elbow joints were decalcified and sectioned for future autoradiography. Scintigraphy, 1 day after injection, indicated slight radioisotope escape from the joint to regional lymph nodes. Serial blood, urine, feces, and organ counts indicated >99.1% of the 117mSn activity was retained in the joint for 45‐47 days. Radiation output levels were below patient release levels the day following injection. Maximum standard uptake value for the injected joint decreased. Joint fluid cytology was unchanged. No dog exhibited lameness during the study. Absence of joint damage and lack of systemic effects after injection of the 117mSn colloid in normal canine elbow joints indicate that this agent may be safely used for radiosynoviorthesis in dogs with osteoarthritis.