Nucleophilic phenylation: a remarkable application of alkoxymethyltriphenylphosphonium salts

A new application of α-alkoxymethylphosphonium salts in the nucleophilic phenylation of carbonyl compounds is demonstrated. Phenylation of aldehydes, ketones and acyl halides were studied by employing α-alkoxymethyltriphenylphosphonium halides in the presence of lithium hydroxide. Graphic abstract N...

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Bibliographic Details
Published in:Molecular diversity 2020-05, Vol.24 (2), p.455-462
Main Authors: Cheema, Zain Maqsood, Gondal, Humaira Yasmeen, Raza, Abdul Rauf, Abbaskhan, Ahmed
Format: Article
Language:English
Subjects:
Aldehydes
Aldehydes - chemistry
Biochemistry
Biomedical and Life Sciences
Chlorides - chemistry
Halides
Iodides - chemistry
Ketones
Ketones - chemistry
Life Sciences
Lithium
Organic Chemistry
Organophosphorus Compounds - chemistry
Pharmacy
Polymer Sciences
Progesterone - chemistry
Salts
Short Communication
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Summary:A new application of α-alkoxymethylphosphonium salts in the nucleophilic phenylation of carbonyl compounds is demonstrated. Phenylation of aldehydes, ketones and acyl halides were studied by employing α-alkoxymethyltriphenylphosphonium halides in the presence of lithium hydroxide. Graphic abstract New application of α-alkoxymethyltriphenylphosphonium salts. Metal-free, mild and selective phenylation. Easy preparation and handling of the reagent.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-019-09966-z