Predictive value of left ventricular myocardial strain by four‐dimensional speckle tracking echocardiography combined with red cell distribution width in heart failure with preserved ejection fraction

Objectives The diagnostic difficulty of heart failure with preserved ejection fraction (HFpEF) is differentiating it in patients with similar symptoms and signs. This study aimed to assess the potential predictive value of left ventricular global longitudinal strain (GLS), global radial strain (GRS)...

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Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2019-06, Vol.36 (6), p.1074-1083
Main Authors: Fang, Sihua, Zhang, Zhihua, Wang, Ying, Jiang, Fan, Yang, Kai, He, Fei, Zhang, Chaoxue
Format: Article
Language:English
Subjects:
Aged
Cohort Studies
Cross-Sectional Studies
Diagnosis, Differential
Echocardiography, Four-Dimensional - methods
Erythrocyte Indices - physiology
Female
Heart Failure - complications
Heart Failure - physiopathology
heart failure with preserved ejection fraction
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Male
Middle Aged
red cell distribution width
speckle tracking echocardiography
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - physiopathology
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Summary:Objectives The diagnostic difficulty of heart failure with preserved ejection fraction (HFpEF) is differentiating it in patients with similar symptoms and signs. This study aimed to assess the potential predictive value of left ventricular global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), and global area strain (GAS) measured by four‐dimensional speckle tracking echocardiography (4DSTE) combined with red cell distribution width (RDW) in patients with HFpEF. Methods One hundred and sixty‐nine patients with symptoms or signs indicative of chronic heart failure and a left ventricular ejection fraction (LVEF) ≥ 50% and fifty controls with normal LVEF were recruited in this study. Standard echocardiography and 4DSTE examinations were performed. Laboratory examinations including RDW were performed on the same day as the echocardiographic study. Results GLS, GCS, GRS, and GAS in the patient cohort were significantly lower, and RDW was significantly higher than those in the control cohort (P 
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.14373