Transdermal delivery of fluvastatin loaded nanoemulsion gel: Preparation, characterization and in vivo anti-osteoporosis activity

• Published in: European journal of pharmaceutical sciences 2019-08, Vol.136, p.104956-104956, Article 104956
• Main Authors: Kaur, Ramandeep, Ajitha, Makula
• Format: Article
• Language: English
• Subjects: Acrylic Resins - chemistry; Administration, Cutaneous; Animals; Drug Carriers - chemistry; Drug Delivery Systems - methods; Emulsions - administration & dosage; Emulsions - chemistry; Fluvastatin; Fluvastatin - administration & dosage; Fluvastatin - chemistry; Gels - administration & dosage; Gels - chemistry; Nanoemulsion gel; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanotechnology - methods; Osteoporosis; Osteoporosis - drug therapy; Particle Size; Rats; Skin - metabolism; Skin Absorption - drug effects; Transdermal; Viscosity - drug effects
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/j.ejps.2019.104956

The objective of present study was to develop hydrogel based nanoemulsion (NE) drug delivery system for transdermal delivery and evaluate its potential in in vivo anti-osteoporotic activity. NE was prepared using aqueous phase titration method and characterized for droplet size, zeta potential and morphology. It was then formulated into hydrogel based NE gel using carbopol 940 as gelling agent. NE gel was evaluated for pH, viscosity, in vitro/ex vivo permeation studies and in vivo anti-osteoporotic activity. The results indicated formation of spherical, nano sized globules of NE ranging from 11.17 ± 0.24 to 128.8 ± 0.16 nm with polydispersity of