One step hydrothermal functionalization of gold nanoparticles with folic acid

[Display omitted] •A new one-step facile method for in-situ GNPs biofunctionalization is described.•Functionalization was performed using hydrothermal treatment of folate and GNPs suspension.•Hydrothermal treatment increases the light emission from the pterin moiety of folate.•Successful functionali...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-09, Vol.181, p.533-538
Main Authors: Vostrikova, Anna M., Kokorina, Alina A., Mitrophanova, Anastassia N., Sindeeva, Olga A., Sapelkin, Andrei V., Sukhorukov, Gleb B., Goryacheva, Irina Y.
Format: Article
Language:English
Subjects:
Animals
Biological ligand
Cattle
Folic acid
Folic Acid - chemistry
Functionalization
Gold - chemistry
Gold nanoparticles
Hydrothermal treatment
Immunoglobulin G - chemistry
Metal Nanoparticles - chemistry
Mice
Molecular Structure
Serum Albumin, Bovine - chemistry
Temperature
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Summary:[Display omitted] •A new one-step facile method for in-situ GNPs biofunctionalization is described.•Functionalization was performed using hydrothermal treatment of folate and GNPs suspension.•Hydrothermal treatment increases the light emission from the pterin moiety of folate.•Successful functionalization of GNPs with folate is confirmed by binding with specific antibody. A new fundamental concept for one-step in-situ functionalization of gold nanoparticles (GNPs) with folic acid using hydrothermal treatment is described. Hydrothermal treatment has been tuned to increase the light emission from the pterin moiety of folic acid molecule, while retain its structure and functionality, thus providing a simple route to multimodal tags for a variety of in vitro and in vivo biomedical applications. Successful functionalization of GNPs with the biological ligand is confirmed by specific binding with anti-folic acid antibody.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2019.05.072