Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

• Published in: Bioorganic chemistry 2019-08, Vol.89, p.103021-103021, Article 103021
• Main Authors: Kumari, Archana, Singh, Rajesh K.
• Format: Article
• Language: English
• Subjects: Indole nucleus; Medicinal Chemistry; Pharmacological profile; Structure-activity relationship; Synthesis
• ISSN: 0045-2068; 1090-2120
• DOI: 10.1016/j.bioorg.2019.103021

[Display omitted] •Indole heterocyclic molecules have huge significance in the field of medicinal chemistry.•The present review focus on synthetic medicinal chemistry, SAR and pharmacological significance of indole derivatives.•Clinical and preclinical indole derivatives and their mechanism of actions are also illustrated. Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic compound with wide ranges of pharmacological activities due to different mechanisms of action. It is an superlative moiety in drug discovery with the sole property of resembling different structures of the protein. Plenty of research has been taking place in recent years to synthesize and explore the various therapeutic prospectives of this moiety. This review summarizes some of the recent effective chemical synthesis (2014–2018) for indole ring. This review also emphasized on the structure–activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years. The precise features with motives and framework of each research topic is introduced for helping the medicinal chemists to understand the perspective of the context in a better way. This review will definitely offer the platform for researchers to strategically design diverse novel indole derivatives having different promising pharmacological activities with reduced toxicity and side effects.